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1.
Children (Basel) ; 11(1)2024 Jan 18.
Artigo em Inglês | MEDLINE | ID: mdl-38255432

RESUMO

Currently, the use of digital tools has led to significant changes in the educational system, favouring equity and the inclusion of students with educational needs. In this context, students with autism spectrum disorder (ASD) benefit from using these electronic devices to improve their learning experience. This study focuses on conducting a bibliometric analysis of the impact of information and communication technologies on the learning of students with ASD, with the aim of addressing two research questions. Through the analysis of three databases (Scopus, Dialnet, and Web of Science), a total of 24 articles related to the subject were collected. The results show that the use of different technological devices has numerous benefits for these students. Among the most prominent are the use of augmented reality and educational robotics, mainly providing improvements in academic performance, motivation and improved retention of knowledge acquired in the classroom. In conclusion, the clear need to train teachers in digital competencies and to intensify efforts in this line of research in order to improve the education of students, as well as to enrich the knowledge available to the scientific community, is highlighted.

2.
Hypertension ; 80(11): 2485-2493, 2023 11.
Artigo em Inglês | MEDLINE | ID: mdl-37694400

RESUMO

BACKGROUND: Guidelines recommend pharmacological treatment for systolic blood pressure (SBP) of 130 to 139 mm Hg in secondary prevention. However, uncertainty persists in primary prevention in low cardiovascular risk patients (CVR). METHODS: Cohort study representative of the general population of Albacete/Southeast Spain. We examined 1029 participants with untreated blood pressure and free of cardiovascular disease, followed-up during 1992 to 2019. Cox regression modeled the association of SBP with cardiovascular morbidity and mortality (outcome-1) and cardiovascular morbidity and all-cause mortality (outcome-2). RESULTS: Participants' mean age was 44.8 years (53.8%, women; 77.1% at low-CVR); 20.3% had SBP 120 to 129; 13.0% 130 to 139 at low-CVR and 3.4% at high-CVR; and 27.4% ≥140 mm Hg. After a 25.7-year median follow-up, 218 outcome-1 and 302 outcome-2 cases occurred. Unadjusted hazard ratios of outcome-1 for these increasing SBP categories (versus <120) were 2.72, 2.27, 11.54, and 7.52, respectively; and 2.69, 2.32, 10.55, and 7.34 for outcome-2 (all P<0.01). After adjustment for other risk factors, hazard ratio (95% CI) of outcome-1 were 1.49 (0.91-2.44), 1.65 (0.94-2.91, P=0.08), 1.36 (0.72-2.57), and 1.82 (1.15-2.88), respectively, and 1.39 (0.91-2.11), 1.69 (1.05-2.73), 1.09 (0.63-1.88), and 1.64 (1.11-2.41) for outcome-2. Compared with 130 to 139 at low-CVR, hazard ratio for 130 to 139 at high-CVR was 4.85 for outcome-1 (P<0.001) and 4.43 for outcome-2 (P<0.001). CONCLUSIONS: In this primary prevention population of relatively young average age, untreated SBP of 130 to 139 mm Hg at low-CVR had long-term prognostic value and might benefit from stricter SBP targets. High-CVR patients had nonsignificant higher risk (limited sample size) but 4-fold greater risk when compared with low-CVR. Overall, results indicate the importance of risk stratification, supporting risk-based decision-making.


Assuntos
Doenças Cardiovasculares , Hipertensão , Humanos , Feminino , Adulto , Masculino , Pressão Sanguínea/fisiologia , Hipertensão/tratamento farmacológico , Hipertensão/epidemiologia , Hipertensão/complicações , Estudos de Coortes , Estudos Prospectivos , Doenças Cardiovasculares/diagnóstico , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/complicações , Prognóstico , Fatores de Risco
3.
Proc Biol Sci ; 290(2001): 20230344, 2023 06 28.
Artigo em Inglês | MEDLINE | ID: mdl-37357858

RESUMO

Ecological theory posits that temporal stability patterns in plant populations are associated with differences in species' ecological strategies. However, empirical evidence is lacking about which traits, or trade-offs, underlie species stability, especially across different biomes. We compiled a worldwide collection of long-term permanent vegetation records (greater than 7000 plots from 78 datasets) from a large range of habitats which we combined with existing trait databases. We tested whether the observed inter-annual variability in species abundance (coefficient of variation) was related to multiple individual traits. We found that populations with greater leaf dry matter content and seed mass were more stable over time. Despite the variability explained by these traits being low, their effect was consistent across different datasets. Other traits played a significant, albeit weaker, role in species stability, and the inclusion of multi-variate axes or phylogeny did not substantially modify nor improve predictions. These results provide empirical evidence and highlight the relevance of specific ecological trade-offs, i.e. in different resource-use and dispersal strategies, for plant populations stability across multiple biomes. Further research is, however, necessary to integrate and evaluate the role of other specific traits, often not available in databases, and intraspecific trait variability in modulating species stability.


Assuntos
Ecossistema , Plantas , Filogenia , Sementes , Fenótipo , Folhas de Planta
4.
Artigo em Inglês | MEDLINE | ID: mdl-36767938

RESUMO

Higher education institutions moving towards the inclusive education model have to offer quality education for all students. In this sense, the use of technologies favours not only the education of people with disabilities, but also their quality of life. However, these people may encounter real problems of access to technologies due, among other factors, to the lack of teacher training, causing a public health problem. In this line, our study includes a systematic review of the literature that aims to know the impact of the technological training of university teachers in relation to educational inclusion and the improvement of the quality of life of students with disabilities. To this end, a search of the literature published in the last decade was carried out in six databases (Dialnet, Google Scholar, Scopus, Web of Science, ERIC, and SciELO), selecting 14 articles out of 1204 initial ones. The studies were analysed following the PRISMA methodology. The main findings are the scarcity of research literature on the digital competence of university teachers and its impact on the educational inclusion and quality of life of students with disabilities. Likewise, there is a clear lack of knowledge about the use of digital tools and a lack of knowledge about the different disabilities that teachers may encounter in higher education classrooms.


Assuntos
Pessoas com Deficiência , Capacitação de Professores , Humanos , Qualidade de Vida , Universidades , Estudantes
5.
Spectrochim Acta A Mol Biomol Spectrosc ; 293: 122450, 2023 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-36753918

RESUMO

Composting olive mill pomace (OMP), the major by-product of the olive oil industry, is an attractive waste management practice in the context of sustainable food production. Thermal treatment of compost at mild temperatures (torrefaction) can aid to improve its characteristics as a soil amendment. This study aims to understand the chemical changes occurring during torrefaction of olive mill pomace-based (OMP) compost, as well as to evaluate the treatment effects on compost at different stages of maturation. Here, treatments at different temperatures (175, 225, and 275 °C) and duration (from 1 to 5 h) have been employed to obtain a sort of torrefied samples. In general, the H/C and O/C atomic ratios of compost samples decreased with torrefaction temperatures, which suggests an incipient coalification of the organic matter. Furthermore, the results showed that a combination of FT-NIR and FT-MIR spectroscopy using a low-level data fusion strategy is very sensitive to the molecular changes occurring both in the composting process and during heating. Principal Component Analysis (PCA) of the merged spectra revealed that the changes at 175 °C are mainly the loss of water (O-H contributions at 3300 and 5169 cm-1) together with the degradation of proteins (observed in the decrease of amide I and II characteristic bands). Furthermore, the samples heated at this temperature can still be differentiated by their initial maturation stage. On the other hand, thermochemical changes occurring at higher temperatures are more intense and make the samples more alike, independently of the composting time. When heating above 225 °C, the loss of O-H happens together with the decrease of aliphatic moieties, reflected in the bands 2920 and 2850 cm-1 (FT-MIR) and 4258, 4323, 5665, and 5781 cm-1 (FT-MIR). This can be attributed to the thermal degradation of cellulosic materials and, additionally, to the degradation of the residual oil in the case of poorly composted samples. Heated samples are characterized by the presence of carbonyl groups (1709 cm-1) and humic-like complex and polymerized aromatic structures (1579 cm-1). Since the characteristics of the torrefied compost at 275 °C are very similar regardless of the initial maturation stage, torrefaction may be a very interesting way to reduce the composting time of olive mill pomace to obtain a high-quality organic amendment for soil application.


Assuntos
Compostagem , Olea , Olea/química , Quimiometria , Resíduos Industriais/análise , Solo/química , Espectrofotometria Infravermelho
7.
Commun Biol ; 6(1): 47, 2023 01 13.
Artigo em Inglês | MEDLINE | ID: mdl-36639596

RESUMO

Previous attempts to quantify tree abundance at global scale have largely neglected the role of local competition in modulating the influence of climate and soils on tree density. Here, we evaluated whether mean tree size in the world's natural forests alters the effect of global productivity on tree density. In doing so, we gathered a vast set of forest inventories including >3000 sampling plots from 23 well-conserved areas worldwide to encompass (as much as possible) the main forest biomes on Earth. We evidence that latitudinal productivity patterns of tree density become evident as large trees become dominant. Global estimates of tree abundance should, therefore, consider dependencies of latitudinal sources of variability on local biotic influences to avoid underestimating the number of trees on Earth and to properly evaluate the functional and social consequences.


Assuntos
Florestas , Árvores , Ecossistema , Clima , Mudança Climática
9.
Artigo em Inglês | MEDLINE | ID: mdl-36231217

RESUMO

Access to university is a right for all people; however, access to higher education for people with disabilities is still a challenge. The present study, based on a systematic review of the literature, aims to report on the challenges faced by students with disabilities in accessing and participating in higher education. The systematic review of four databases resulted in 20 studies published between 2011 and 2021. The results indicate that students with disabilities face numerous challenges in accessing university education. Based on the results, strategies are proposed in order to provide equal opportunities and success in higher education for students with disabilities.


Assuntos
Pessoas com Deficiência , Escolaridade , Humanos , Estudantes , Revisões Sistemáticas como Assunto , Universidades
10.
Heliyon ; 8(8): e10139, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-35965985

RESUMO

The COVID-19 pandemic caused changes in higher education institutions, mainly due to the temporary closure of face-to-face activities in universities worldwide. The transformation from face-to-face to online education was one of the emerging solutions to this crisis. This research aims to analyse and describe the adaptation process from face-to-face to online education and the perceptions of faculty and students during the pandemic in a literature review study. We developed this study following the methodology supported by the PRISMA statement and the PICoS strategy, retrieving scientific literature from Web of Science, Scopus, ERIC and PsycINFO. Of the 241 studies that the search yielded, 29 have been included. The results showed that online education was an enabling alternative for the development of higher education, but numerous weaknesses in the transition to online education were identified. The study concludes that online learning is a future direction in higher education. Therefore, institutions should invest more in online education platforms and improve faculty training plans.

11.
Artigo em Inglês | MEDLINE | ID: mdl-33440738

RESUMO

Educational technology has become an increasingly important element for improving the teaching and learning process of students. To achieve these goals, it is essential that teachers have the skills they need to be able to introduce technology into their teaching practice. However, this is often overwhelming and stressful for many of them. The aim of this review was to find out how research on teacher stress and anxiety associated with the use of educational technology was proceeding. A systematic review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines through the following bibliographic databases: PubMed, Web of Science, and Scopus. Sixteen articles were found from the review. The main findings show that teachers present high levels of anxiety or stress due to their use of educational technology in the classroom. Among the conclusions, the need for research on different strategies to prevent the emergence of these anxiety and stress symptoms in teachers stands out.


Assuntos
Transtornos de Ansiedade , Ansiedade , Tecnologia Educacional , Humanos , Aprendizagem , Estudantes
12.
Foods ; 10(1)2021 Jan 03.
Artigo em Inglês | MEDLINE | ID: mdl-33401573

RESUMO

There is a growing interest of researchers in meat authentication in terms of geographical and dietary background of animals, and several analytical methods have been proposed for the purpose of investigating this. We hypothesized that the odd- and branched-chain fatty acid (OBCFA) profile in intramuscular fat (IMF) might suffice to distinguish lamb meat entering the food chain supply on the basis of the type of diet fed to lambs during the fattening period. A total of 30 individual OBCFA profiles, quantified by gas chromatography, of IMF of Manchego lambs were used. During the fattening period (42 days), the lambs were fed three diets differing in concentrate composition: (i) Control, concentrate typical of commercial fattening rations, rich in starch and based on cereals and soybean meal; (ii) Camelina, similar to Control but replacing 50% of the soybean meal with camelina meal; and (iii) Fibrous, concentrate rich in neutral detergent fiber (NDF), based on fibrous by-products and not including cereals nor soybean meal. The OBCFA were grouped into three classes (linear odd, iso and anteiso fatty acids) and were then submitted to a linear discriminant analysis, using the feeding treatments as grouping variable and the OBCFA class contents in IMF as quantitative variables. The results suggested that a high NDF to starch ratio of the concentrate, being the lowest for Control (CON) treatment and the highest for Fibrous (FIB) treatment, would be negatively related to the odd/anteiso ratio and positively related to the iso/(anteiso+odd) FA ratio in IMF. Determination of OBCFA profile in lamb meat would be useful to monitor the feeding regime (starch- or NDF-rich) of lambs entering the food chain supply.

13.
Nat Commun ; 11(1): 5635, 2020 11 06.
Artigo em Inglês | MEDLINE | ID: mdl-33159062

RESUMO

More tree species can increase the carbon storage capacity of forests (here referred to as the more species hypothesis) through increased tree productivity and tree abundance resulting from complementarity, but they can also be the consequence of increased tree abundance through increased available energy (more individuals hypothesis). To test these two contrasting hypotheses, we analyse the most plausible pathways in the richness-abundance relationship and its stability along global climatic gradients. We show that positive effect of species richness on tree abundance only prevails in eight of the twenty-three forest regions considered in this study. In the other forest regions, any benefit from having more species is just as likely (9 regions) or even less likely (6 regions) than the effects of having more individuals. We demonstrate that diversity effects prevail in the most productive environments, and abundance effects become dominant towards the most limiting conditions. These findings can contribute to refining cost-effective mitigation strategies based on fostering carbon storage through increased tree diversity. Specifically, in less productive environments, mitigation measures should promote abundance of locally adapted and stress tolerant tree species instead of increasing species richness.


Assuntos
Clima , Ecossistema , Árvores/crescimento & desenvolvimento , Biodiversidade , Carbono/metabolismo , Florestas , Árvores/classificação , Árvores/metabolismo
14.
Rev. bras. educ. espec ; 26(4): 711-732, out.-dez. 2020. tab, graf
Artigo em Espanhol | LILACS-Express | LILACS | ID: biblio-1144047

RESUMO

RESUMEN: La formación del profesorado es necesaria y esencial para desarrollar una educación de calidad en igualdad y equidad. En este contexto, las Tecnologías de la Información y la Comunicación (TIC) abren una nueva forma de acceder a la información y un gran puente de comunicación, ya que para algunas personas las tecnologías constituyen la única vía de acceso al mundo educativo y de la cultura. El propósito de este estudio es realizar una revisión sistemática entorno a la producción, en forma de artículos científicos, durante la última década en relación con la formación del profesorado en TIC como apoyo al alumnado con discapacidad. Se realizó una búsqueda en las bases de datos Web of Science y Scopus siguiendo las directrices de la declaración PRISMA y la estrategia PICoS. De un total de 143 artículos fueron seleccionados 22. Los principales resultados muestran un incremento creciente en el número de publicaciones, sin embargo, su impacto sigue siendo escaso. Entre las conclusiones se destaca que la escasa existencia de literatura científica es uno de los principales problemas que pueden dificultar la formación del profesorado.


ABSTRACT: Teacher training is necessary and essential to develop a quality education in equality and equity. In this context, Information and Communication Technologies (ICT) open a new way of accessing information and a great communication bridge, since for some people technologies are the only way to access the world of education and culture. The purpose of this study is to carry out a systematic review on the production, in the form of scientific articles, during the last decade in relation to the training of teachers in ICT to support students with disabilities. A search of the Web of Science and Scopus databases was performed following the guidelines of the PRISMA statement and the PICoS strategy. From a total of 143 articles, 22 were selected. The main results show an increase in the number of publications; however, their impact is still low. Among the conclusions, we highlight that the scarce existence of scientific literature is one of the main problems that can hinder teacher training.

15.
Proc Natl Acad Sci U S A ; 117(39): 24345-24351, 2020 09 29.
Artigo em Inglês | MEDLINE | ID: mdl-32900958

RESUMO

The stability of ecological communities is critical for the stable provisioning of ecosystem services, such as food and forage production, carbon sequestration, and soil fertility. Greater biodiversity is expected to enhance stability across years by decreasing synchrony among species, but the drivers of stability in nature remain poorly resolved. Our analysis of time series from 79 datasets across the world showed that stability was associated more strongly with the degree of synchrony among dominant species than with species richness. The relatively weak influence of species richness is consistent with theory predicting that the effect of richness on stability weakens when synchrony is higher than expected under random fluctuations, which was the case in most communities. Land management, nutrient addition, and climate change treatments had relatively weak and varying effects on stability, modifying how species richness, synchrony, and stability interact. Our results demonstrate the prevalence of biotic drivers on ecosystem stability, with the potential for environmental drivers to alter the intricate relationship among richness, synchrony, and stability.


Assuntos
Plantas/classificação , Sequestro de Carbono , Mudança Climática , Ecossistema , Desenvolvimento Vegetal , Plantas/metabolismo , Solo/química
16.
J Cardiovasc Nurs ; 35(2): 210-216, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31904694

RESUMO

BACKGROUND: Clustering of cardiovascular risk factors (CVRFs) is extraordinarily common and is associated with an increased risk of cardiovascular disease (CVD). However, the particular impact of the sum of CVRFs on cardiovascular morbidity and mortality has not been sufficiently explored in Europe. OBJECTIVE: The aim of this study was to analyze the differences in survival-free probability of CVD in relation to the number of CVRFs in a Spanish population. METHODS: A prospective cohort study was conducted from 1992 to 2016 in a Spanish population that included 1144 subjects with no history of CVD (mean age, 46.7 years) drawn from the general population. We calculated the number of CVRFs for each subject (male sex, smoking, diabetes, hypertension, dyslipidemia, obesity, and left ventricular hypertrophy). Cardiovascular morbidity and mortality records were collected, and survival analysis was applied (competing risk models). RESULTS: There were 196 cardiovascular events (17.1%). The differences in total survival-free probability of cardiovascular morbidity and mortality of the different values of the sum of CVRFs were significant, increasing the risk of CVD (hazard ratio, 1.30; 95% confidence interval, 1.13-1.50) per each additional risk factor. CONCLUSION: Differences in survival-free probability of CVD in relation to the number of CVRFs present were statistically significant. Further studies are needed to corroborate our results.


Assuntos
Doenças Cardiovasculares/epidemiologia , Fatores de Risco de Doenças Cardíacas , Adulto , Análise por Conglomerados , Feminino , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Fatores de Risco , Fatores de Tempo
17.
Ecol Lett ; 22(8): 1297-1305, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31190431

RESUMO

Zoogeographical regions, or zooregions, are areas of the Earth defined by species pools that reflect ecological, historical and evolutionary processes acting over millions of years. Consequently, researchers have assumed that zooregions are robust and unlikely to change on a human timescale. However, the increasing number of human-mediated introductions and extinctions can challenge this assumption. By delineating zooregions with a network-based algorithm, here we show that introductions and extinctions are altering the zooregions we know today. Introductions are homogenising the Eurasian and African mammal zooregions and also triggering less intuitive effects in birds and amphibians, such as dividing and redefining zooregions representing the Old and New World. Furthermore, these Old and New World amphibian zooregions are no longer detected when considering introductions plus extinctions of the most threatened species. Our findings highlight the profound and far-reaching impact of human activity and call for identifying and protecting the uniqueness of biotic assemblages.


Assuntos
Anfíbios , Aves , Espécies em Perigo de Extinção , Atividades Humanas , Animais , Biodiversidade , Conservação dos Recursos Naturais , Extinção Biológica , Humanos , Mamíferos
18.
Alerg. inmunol. clin ; 38(1-2): 25-25, alerg. inmunol. clin. Vol.38 (1) año 2019.
Artigo em Espanhol | LILACS-Express | LILACS | ID: biblio-1140878
19.
J Cardiovasc Nurs ; 33(6): E17-E23, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30273261

RESUMO

BACKGROUND: Although studies exist comparing low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (HDL-C) in the development of cardiovascular disease (CVD), most have limitations in the mathematical models used to evaluate their prognostic power adjusted for the other risk factors (cardiovascular risk). OBJECTIVE: The aim of this study was to compare LDL-C and non-HDL-C in patients with CVD to determine whether both parameters predict CVD similarly. METHODS: A cohort of 1322 subjects drawn from the general population of a Spanish region was followed between 1992 and 2006. The outcome was time to CVD. Secondary variables were gender, age, hypertension, diabetes, personal history of CVD, current smoker, body mass index, LDL-C, and non-HDL-C. Two CVD prediction models were constructed with the secondary variables, with only the lipid parameter varying (non-HDL-C or LDL-C). In the construction of the models, the following were considered: multiple imputation, events per variable of 10 or more, and continuous predictors as powers. The validation was conducted by bootstrapping obtaining the distribution of the C statistic (discrimination) and the probabilities observed by smooth curves. These results were compared in both models using graphical and analytical testing. RESULTS: There were a total of 137 CVD events. The models showed no differences in the distributions of the C statistic (discrimination, P = .536) or in the calibration plot. CONCLUSIONS: In our population, LDL-C and non-HDL-C were equivalent at predicting CVD. More studies using this methodology are needed to confirm these results.


Assuntos
Doenças Cardiovasculares/epidemiologia , LDL-Colesterol/sangue , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Modelos Estatísticos , Análise Multivariada , Valor Preditivo dos Testes , Medição de Risco/métodos
20.
Clín. investig. arterioscler. (Ed. impr.) ; 30(2): 64-71, mar.-abr. 2018. graf, tab
Artigo em Espanhol | IBECS | ID: ibc-172068

RESUMO

Introducción: El colesterol no transportado por las lipoproteínas de alta densidad (c-no-HDL) está adquiriendo relevancia en su participación en la valoración del riesgo cardiovascular y como diana terapéutica. El objetivo del presente estudio ha sido valorar la capacidad predictiva independiente, tanto del c-no-HDL como del colesterol de las lipoproteínas de baja densidad (cLDL), principal prioridad en las dislipidemias para reducir el riesgo cardiovascular (RCV), en la morbilidad de causa cardiovascular, en una muestra de origen poblacional. Métodos: El diseño del estudio corresponde a una cohorte prospectiva en la que han participado 1.186 individuos en el grupo c-no-HDL y 1.177 en el grupo cLDL, seguidos durante 10,7años (DE=2,2), los cuales no habían padecido ningún episodio cardiovascular (CV) previo. Las variables predictoras incluidas en el ajuste han sido: género, edad, hipertensión arterial, diabetes mellitus, estado de fumador y c-no-HDL en un grupo. En el otro grupo, formado por pacientes que presentaban niveles de triglicéridos ≤400mg/dl, se sustituyó el c-no-HDL por el cLDL. Se calcularon curvas de supervivencia (Kaplan-Meier) y se aplicaron dos modelos de regresión de Cox, uno por cada grupo.Resultados: El grupo c-no-HDL presentó un 6,2% de episodios CV no mortales durante el seguimiento, y el grupo cLDL, un 6,0%. Después del ajuste, por cada aumento de 30mg/dl de c-no-HDL, la incidencia de nuevos episodios CV no mortales aumentó un 31% (HR=1,31; IC95%: 1,06-1,61; p=0,018) y en el grupo del cLDL un 27% (HR=1,27; IC95%: 0,97-1,61; p=0,068). Conclusiones: Tras un seguimiento de 10,7años, el c-no-HDL se ha mostrado en nuestra población como un factor pronóstico de enfermedad CV no mortal, pero no el cLDL, aunque su HR se encuentra próxima a la significación estadística (AU)


Introduction: Non-HDL cholesterol (non-HDL-C) is becoming relevant both in its participation in cardiovascular risk assessment and as a therapeutic target. The objective of the present study was to assess the independent predictive capacity of both non-HDL-C and LDL-C (the main priority in dyslipidemias to reduce cardiovascular risk), in cardiovascular morbidity in a population-based sample. Methods: A prospective cohort study involving 1186 individuals in the non-HDL-C group and 1177 in the LDL-C group, followed for 10.7years (SD=2.2), who had not had any previous cardiovascular event. The predictor variables included in the adjustment were: gender, age, arterial hypertension, diabetes mellitus, smoker status and non-HDL-C in one group. In the other group, consisting of patients presenting TG levels of 400mg/dL, non-HDL-C was replaced by LDL-C. Survival curves (Kaplan-Meier) were calculated and two Cox regression models were applied, one for each group. Results: Non-HDL-C group presented 6.2% of non-fatal cardiovascular episodes during follow-up and the LDL-C group 6.0%. After adjustment, for each 30mg/dL increase in non-HDL-C, the incidence of new non-fatal cardiovascular events increased by 31% (HR=1.31, 95%CI: 1.06-1.61; P=.018) and in the LDL-C group by 27% (HR=1.27, 95%CI: 0.97-1.61, P=.068). Conclusions: After a follow-up of 10.7years, non-HDL-C has been shown in our population as a prognostic factor of non-fatal cardiovascular disease, but not LDL-C, although its HR is close to statistical significance (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , HDL-Colesterol/análise , Valor Preditivo dos Testes , Doenças Cardiovasculares/diagnóstico , Doenças Cardiovasculares/prevenção & controle , Fatores de Risco , Estudos Prospectivos , Estudos de Coortes , Estimativa de Kaplan-Meier , Indicadores de Morbimortalidade , 28599
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